Does a High Fat Diet cause Inflammation? (Keto Diet & Inflammation)

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Does a High Fat Diet cause Inflammation? (Keto Diet & Inflammation) - Thomas DeLauer



bHB & Inflammation

beta-hydroxybutyrate can block what’s called the NLRP3 inflammasome, an immune system receptor linked to inflammation

The NLRP3 inflammasome reacts quickly to threats to the body, such as toxins, infections, or too much glucose

While helpful in many cases, this receptor can be activated too much if we’re constantly exposed to inflammation, like from eating inflammatory foods every day

By triggering ketosis, we may be able to help reduce how much the NLRP3 fires in the body
ROS

A ketogenic diet could be beneficial for a number of types of pain, including neuropathic pain, and inflammatory pain Compared to glucose metabolism, ketone metabolism produces fewer reactive oxygen species, which are known to contribute to inflammation

Ketosis & 2-deoxyglucose (2DG): Brain Inflammation

Study from: Raymond Swanson, MD, a professor of neurology at UCSF, chief of the neurology service at the San Francisco Veterans Affairs Medical Center, and senior author of the new study

Study

Researchers used a small molecule called 2-deoxyglucose, or 2DG, to block glucose metabolism and produce a ketogenic state in rats and controlled laboratory cell lines.

Found that 2DG could bring inflammation levels down to almost control levels - The 2DG molecule stopped glucose from metabolizing and created a ketogenic state in rodents with brain inflammation as well as in cell cultures. Levels of inflammation were drastically reduced - almost to healthy levels - as a result.

Also found that reduced glucose metabolism lowered a key barometer of energy metabolism – the NADH/NAD+ ratio – which in turn activated a protein called CtBP that acts to suppress activity of inflammatory genes

The researchers designed a drug-like peptide molecule that blocks the ability of CtBP to enter its inactive state – essentially forcing the protein to constantly block inflammatory gene activity and mimicking the effect of a ketogenic state

The study has applications beyond brain-related inflammation - presence of excess glucose in people with diabetes, for example, is associated with a pro-inflammatory state that often leads to atherosclerosis, the buildup of fatty plaques that can block key arteries

References

1) Ketosis for Reduced Inflammation. (2017, July 13). Retrieved January 04, 2018, from https://www.perfectketo.com/ketosis-for-reduced-inflammation/
2) Masino, S. A., & Ruskin, D. N. (2013, August). Ketogenic Diets and Pain. Retrieved January 04, 2018, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124736/
3) UC San Francisco. (2018). How Ketogenic Diets Curb Inflammation in the Brain. [online] Available at: https://www.ucsf.edu/news/2017/09/408366/how-ketogenic-diets-curb-inflammation-brain
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Keto News
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