Can You Get Rid of Fat Cells? Weird Science!

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Can You Get Rid of Fat Cells? Weird Science! - Thomas DeLauer


A study published in Nature found that the number of fat cells you have remains fairly constant throughout your life, regardless of whether or not you diet, or are thin or fat

From infancy to our early 20s, the number of fat cells in our bodies increase - once we hit our mid-20s, though, we maintain the number of fat cells we have (fat cell numbers level off and stabilize in adulthood)

*Overweight people tend to have more fat cells than slim people*

Though some cells may die, our bodies are quick to replace them - as if we’re programmed, to have a certain number of fat cells

Cell death and production appear to be tightly coupled, so although about 10% of adipocytes die each year, they’re replaced at the same rate

So the number of fat cells stays constant in adulthood in lean and obese and even under extreme conditions - when fat cells die, like all cells do, the body simply creates new ones in its effort to keep the number constant

Neither adipocyte death nor generation rate is altered in obesity, suggesting a tight regulation of fat cell number that is independent of metabolic profile in adulthood

**The catch here is that some people are “born” with more fat cells, and others have less. Just like how some people are taller or shorter than others.**

https://www.ncbi.nlm.nih.gov/pubmed/18454136?otool=karolib&tool=karolinska

Resistance Training - Study

Researchers examined the effects of resistance training (RT) frequency performed 3 times per week (RT3) vs. RT performed 6 times per week (RT6) under volume-equated conditions in resistance-trained men

27 men were randomly allocated to RT3 (n = 14) or RT6 (n = 13) - the supervised training intervention lasted for 6 weeks

Pre-to-post intervention, both groups increased upper-body strength (RT3: +4%; RT6: +6%) and lower-body strength (RT3: +22%; RT6: +18%) with no significant between-group differences

Both groups increased elbow extensor thickness (RT3: +14%; RT6: +11%), rectus femoris thickness (RT3: +5%; RT6: +6%), and vastus intermedius thickness (RT3: +10%; RT6: +11%)

Concluded that when training volume is equated, it seems that RT performed either 3 or 6 times per week can result in similar strength gains over a 6-week training period

Furthermore, under volume-equated conditions, comparable hypertrophy results may also be expected with both RT frequencies

https://www.ncbi.nlm.nih.gov/pubmed/30363041

Keto & RMR - Study

A study published in the journal Nutrition & Metabolism looked to see keto’s effect on permanent weight loss via its effects on RMR

Researchers chose a set of 20 obese patients who followed a low-calorie keto diet in order to induce weight loss (was pretty low calorie; 600-800 kcal) - the subjects lost around 45 lbs each over the course of 4 months

But what they found was that despite the patients’ large weight loss, that weight loss didn’t affect the patients’ RMRs in any significant way - there was no significant differences in their basal RMR and no metabolic adaptations occurred

Researchers concluded that the absent reduction in RMR was not due to increased sympathetic tone, as thyroid hormones, catecholamines, and leptin were reduced at any visit from baseline

The researchers concluded that because the study participants didn’t lose a lot of muscle mass, their RMRs stayed steady and so did the weight loss

The rapid and sustained weight and FM loss induced by VLCK-diet in obese subjects did not induce the expected reduction in RMR, and was concluded that this outcome was likely due to the preservation of lean mass that keto offers

*Ketone bodies exert a restraining influence on muscle protein breakdown - if the muscle is plentifully supplied with other substrates for oxidation (such as fatty acids and ketone bodies, in this case), then the oxidation of muscle protein-derived amino acids is suppressed*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816424/
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Keto Diet
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