Autophagy Fasting, & mTOR Inhibitors - Peter Attia, MD

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Peter Attia, MD, is one of the leading thought leaders in the field of enhancing lifespan through dietary changes, intermittent fasting (IF) and exercise.

In this show, we discuss a range of exciting topics with a focus on enhancing autophagy and inhibiting mTOR through nutrition, fasting and pharmacology.

This episode is brought to you by:

➢ Perfect Keto, the makers of high-quality, low-carb bars, nut butters and MCT oil products.
*Save over 20% OFF: https://www.perfectketo.com/HIH

➢ Subscribe to Peter's Channel: https://www.youtube.com/channel/UCXGAY7QiNeBY7VVNZtqmUxA

➢Check out Peter's Amazing Podcast https://podcasts.apple.com/us/podcast/the-peter-attia-drive/id1400828889

➢Links to full show notes and studies: http://bit.ly/2QWLAAY


-----------------------------------------Lets Connect--------------------------------------

➢Audio Podcasthttps://podcasts.apple.com/us/podcast/high-intensity-health-radio-with-mike-mutzel-ms/id910048041

➢ Mike's Instagram https://www.instagram.com/metabolic_mike

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-------------------------------------- Key Timestamps----------------------------------
Links to full show notes and studies: http://bit.ly/2QWLAAY

04:14: Endurance athletics and lactate testing
06:10: Doping in endurance sports: why cycling is not really clean
08:22 Training adaptations and MCT transporters
10:34 The cori cycle in the liver turns lactate back into glucose. The brain can use lactate directly as a fuel.
11:43 Longevity has no clinical trial.
13:42 Two interventions that offer longevity in animal models: fasting and Rapamycin. Both downregulate mTOR and both support autophagy.
15:35 Rapamycin is used for immune suppression in patients who have had organ transplants.
25:02 Dr. Attia does not use telomere’s as a marker of ageing since so many other things can influence it.
26:48 We need a blood test that measures some sort of signature autophagy.
28:46 Fasting is the single most potent tool in our toolbox of nutrition.
32:53 There are 50 different fasting regimens called intermittent fasting and we have no way to rank them or customize them to people’s goals.
34:20 Every gram of glycogen moves with 3 to 4 grams of water. The water goes into the plasma first and then out again as your body tries to conserve sodium.
41:58 Methionine levels drop quickly in fasting. Leucine levels remain about the same even 7 days in.
43:54 Research found that T4 and T3 decreased in the first 3 days of a fast, but leveled out after that.
45:35 In a fasted state, your body upregulates the enzyme that converts T4 into reverse T3.
50:33 At the end of a fast, Dr. Attia has very low testosterone, but experiences little to no symptoms or reduction in strength.
55:53 The literature on NAD is confusing.
01:00:24 Fasting is the single most important tool for treating metabolic disease and should be a part of any protocol.
01:04:09 People who do not do well on a ketogenic diet may have issues with the enzymes that regulate ketogenesis.
01:07:14 Metformin has a possible use as a longevity agent.
01:11:59 Berberine and Metformin go after the same pathway and probably should not be taken together.
01:21:05 Dr. Attia’s morning routine: He gets up early, listens to a lesson and meditates using apps 10% Happier or Waking Up.
Category
Healthy Living
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