Autophagy Fasting, & mTOR Inhibitors - Peter Attia, MD

Peter Attia, MD, is one of the leading thought leaders in the field of enhancing lifespan through dietary changes, intermittent fasting (IF) and exercise.

In this show, we discuss a range of exciting topics with a focus on enhancing autophagy and inhibiting mTOR through nutrition, fasting and pharmacology.

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➢Links to full show notes and studies:

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Links to full show notes and studies:

04:14: Endurance athletics and lactate testing
06:10: Doping in endurance sports: why cycling is not really clean
08:22 Training adaptations and MCT transporters
10:34 The cori cycle in the liver turns lactate back into glucose. The brain can use lactate directly as a fuel.
11:43 Longevity has no clinical trial.
13:42 Two interventions that offer longevity in animal models: fasting and Rapamycin. Both downregulate mTOR and both support autophagy.
15:35 Rapamycin is used for immune suppression in patients who have had organ transplants.
25:02 Dr. Attia does not use telomere’s as a marker of ageing since so many other things can influence it.
26:48 We need a blood test that measures some sort of signature autophagy.
28:46 Fasting is the single most potent tool in our toolbox of nutrition.
32:53 There are 50 different fasting regimens called intermittent fasting and we have no way to rank them or customize them to people’s goals.
34:20 Every gram of glycogen moves with 3 to 4 grams of water. The water goes into the plasma first and then out again as your body tries to conserve sodium.
41:58 Methionine levels drop quickly in fasting. Leucine levels remain about the same even 7 days in.
43:54 Research found that T4 and T3 decreased in the first 3 days of a fast, but leveled out after that.
45:35 In a fasted state, your body upregulates the enzyme that converts T4 into reverse T3.
50:33 At the end of a fast, Dr. Attia has very low testosterone, but experiences little to no symptoms or reduction in strength.
55:53 The literature on NAD is confusing.
01:00:24 Fasting is the single most important tool for treating metabolic disease and should be a part of any protocol.
01:04:09 People who do not do well on a ketogenic diet may have issues with the enzymes that regulate ketogenesis.
01:07:14 Metformin has a possible use as a longevity agent.
01:11:59 Berberine and Metformin go after the same pathway and probably should not be taken together.
01:21:05 Dr. Attia’s morning routine: He gets up early, listens to a lesson and meditates using apps 10% Happier or Waking Up.
Healthy Living
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